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# TISCH [Tumor Immune Single-cell Hub (TISCH)](http://tisch.comp-genomics.org/home/) is a scRNA-seq database, which focuses on tumor microenvironment (TME). TISCH provides detailed cell-type annotation for all curated datasets, enabling the exploration of TME across different cancer types. ## Release 1 - July 11th, 2020 ### Data statistics - **28 cancer types**. - **79 datasets:** 15 datasets with ICB treatment (10 for human and 5 for mouse), 61 non-ICB datasets and 3 PBMC datasets. - **2,045,746 cells:** 378,392 malignant cells and 1,667,354 non-malignant cells. ### Features - **Gene module:** Search a gene across species and cancer types. - **Single-dataset exploration:** 1. Overview of dataset; 2. Gene expression visualization at both single-cell level (UMAP plot) and cluster level (violin plot); 3. Functional enrichment analysis (GSEA); 4. Download files (cluster-level expression matrices, DE gene table and meta information). - **Multiple-dataset comparison:** Compare expression of genes across multiple datasets.

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