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python code for neural network for classification of an image
muhanned.zip
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内容介绍
<html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta charset="utf-8"> <meta name="generator" content="pdf2htmlEX"> <meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"> <link rel="stylesheet" href="https://static.pudn.com/base/css/base.min.css"> <link rel="stylesheet" href="https://static.pudn.com/base/css/fancy.min.css"> <link rel="stylesheet" href="https://static.pudn.com/prod/directory_preview_static/626bd9621e41a87e8aa93c2c/raw.css"> <script src="https://static.pudn.com/base/js/compatibility.min.js"></script> <script src="https://static.pudn.com/base/js/pdf2htmlEX.min.js"></script> <script> try{ pdf2htmlEX.defaultViewer = new pdf2htmlEX.Viewer({}); }catch(e){} </script> <title></title> </head> <body> <div id="sidebar" style="display: none"> <div id="outline"> </div> </div> <div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://static.pudn.com/prod/directory_preview_static/626bd9621e41a87e8aa93c2c/bg1.jpg"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls0 ws0">Magnetic<span class="_ _0"> </span>Resonance<span class="_ _0"> </span>Imaging<span class="_ _0"> </span>of<span class="_ _0"> </span>the<span class="_ _0"> </span>Axial<span class="_ _0"> </span>Skeleton<span class="_ _0"> </span>for</div><div class="t m0 x1 h2 y2 ff1 fs0 fc0 sc0 ls0 ws0">Detecting<span class="_ _0"> </span>Bone<span class="_ _0"> </span>Metastases<span class="_ _0"> </span>in<span class="_ _0"> </span>Patients<span class="_ _0"> </span>With<span class="_ _0"> </span>High-Risk</div><div class="t m0 x1 h2 y3 ff1 fs0 fc0 sc0 ls0 ws0">Prostate<span class="_ _0"> </span>Cancer:<span class="_ _0"> </span>Diagnostic<span class="_ _0"> </span>and<span class="_ _0"> </span>Cost-Effectiveness<span class="_ _0"> </span>and</div><div class="t m0 x1 h2 y4 ff1 fs0 fc0 sc0 ls0 ws0">Comparison<span class="_ _0"> </span>With<span class="_ _0"> </span>Current<span class="_ _0"> </span>Detection<span class="_ _0"> </span>Strategies</div><div class="t m0 x1 h3 y5 ff2 fs1 fc0 sc0 ls0 ws0">Fr&#233;d&#233;ric<span class="_ _1"> </span>E.<span class="_ _1"> </span>Lecouvet,<span class="_ _1"> </span>Daphn&#233;<span class="_ _1"> </span>Geukens,<span class="_ _1"> </span>Annabelle<span class="_ _1"> </span>Stainier,<span class="_ _1"> </span>Franc<span class="_ _2"></span>&#184;ois<span class="_ _1"> </span>Jamar,<span class="_ _1"> </span>Jacques<span class="_ _1"> </span>Jamart,</div><div class="t m0 x1 h3 y6 ff2 fs1 fc0 sc0 ls0 ws0">Bertrand<span class="_ _1"> </span>Janne<span class="_ _1"> </span>d&#8217;Oth&#233;e,<span class="_ _1"> </span>Patrick<span class="_ _1"> </span>Therasse,<span class="_ _1"> </span>Bruno<span class="_ _1"> </span>Vande<span class="_ _1"> </span>Berg,<span class="_ _1"> </span>and<span class="_ _1"> </span>Bertrand<span class="_ _1"> </span>Tombal</div><div class="t m0 x2 h4 y7 ff3 fs2 fc0 sc0 ls1 ws0">ABSTRACT</div><div class="t m0 x1 h5 y8 ff3 fs1 fc0 sc0 ls0 ws0">Purpose</div><div class="t m0 x1 h6 y9 ff4 fs1 fc0 sc0 ls0 ws0">To<span class="_ _3"> </span>evaluate<span class="_ _3"> </span>the<span class="_ _3"> </span>diagnostic<span class="_ _3"> </span>performance,<span class="_ _3"> </span>costs,<span class="_ _3"> </span>and<span class="_ _3"> </span>impact<span class="_ _3"> </span>on<span class="_ _3"> </span>therapy<span class="_ _3"> </span>of<span class="_ _3"> </span>one-step<span class="_ _3"> </span>magnetic</div><div class="t m0 x1 h6 ya ff4 fs1 fc0 sc0 ls0 ws0">resonance<span class="_ _4"> </span>imaging<span class="_ _4"> </span>(MRI)<span class="_ _4"> </span>of<span class="_ _4"> </span>the<span class="_ _4"> </span>axial<span class="_ _4"> </span>skeleton<span class="_ _4"> </span>(MRIas)<span class="_ _4"> </span>for<span class="_ _4"> </span>detecting<span class="_ _4"> </span>bone<span class="_ _4"> </span>metastases<span class="_ _4"> </span>in<span class="_ _4"> </span>patients</div><div class="t m0 x1 h6 yb ff4 fs1 fc0 sc0 ls0 ws0">with<span class="_ _5"> </span>high-risk<span class="_ _5"> </span>prostate<span class="_ _5"> </span>cancer<span class="_ _5"> </span>(PCa).</div><div class="t m0 x1 h5 yc ff3 fs1 fc0 sc0 ls0 ws0">Patients<span class="_ _5"> </span>and<span class="_ _5"> </span>Methods</div><div class="t m0 x1 h6 yd ff4 fs1 fc0 sc0 ls0 ws0">Sixty-six<span class="_ _1"> </span>consecutive<span class="_ _1"> </span>patients<span class="_ _6"> </span>with<span class="_ _1"> </span>high-risk<span class="_ _1"> </span>PCa<span class="_ _6"> </span>prospectively<span class="_ _1"> </span>underwent<span class="_ _1"> </span>MRIas<span class="_ _6"> </span>in<span class="_ _1"> </span>addition<span class="_ _1"> </span>to<span class="_ _6"> </span>the</div><div class="t m0 x1 h6 ye ff4 fs1 fc0 sc0 ls0 ws0">standard<span class="_ _7"> </span>sequential<span class="_ _7"> </span>work-up<span class="_ _7"> </span>(SW)<span class="_ _7"> </span>of<span class="_ _7"> </span>bone<span class="_ _7"> </span>metastases<span class="_ _7"> </span>(technetium-99m<span class="_ _7"> </span>bone<span class="_ _7"> </span>scintigraphy<span class="_ _7"> </span>[BS]</div><div class="t m0 x1 h6 yf ff4 fs1 fc0 sc0 ls0 ws0">completed<span class="_ _1"> </span>with<span class="_ _1"> </span>targeted<span class="_ _1"> </span>x-rays<span class="_ _1"> </span>[TXR]<span class="_ _1"> </span>in<span class="_ _1"> </span>patients<span class="_ _1"> </span>with<span class="_ _1"> </span>equivocal<span class="_ _1"> </span>BS<span class="_ _1"> </span>&#64257;ndings<span class="_ _1"> </span>and<span class="_ _1"> </span>with<span class="_ _1"> </span>MRI<span class="_ _1"> </span>obtained</div><div class="t m0 x1 h6 y10 ff4 fs1 fc0 sc0 ls0 ws0">on<span class="_ _8"> </span>request<span class="_ _8"> </span>[MRIor]<span class="_ _8"> </span>in<span class="_ _8"> </span>patients<span class="_ _8"> </span>with<span class="_ _8"> </span>inconclusive<span class="_ _8"> </span>BS/TXR<span class="_ _8"> </span>&#64257;ndings).<span class="_ _8"> </span>Panel<span class="_ _8"> </span>review<span class="_ _8"> </span>of<span class="_ _8"> </span>initial<span class="_ _8"> </span>and</div><div class="t m0 x1 h6 y11 ff4 fs1 fc0 sc0 ls0 ws0">6-month<span class="_ _8"> </span>follow-up<span class="_ _3"> </span>MRI<span class="_ _3"> </span>&#64257;ndings,<span class="_ _8"> </span>BS/TXR,<span class="_ _3"> </span>and<span class="_ _3"> </span>all<span class="_ _8"> </span>available<span class="_ _3"> </span>baseline<span class="_ _3"> </span>and<span class="_ _8"> </span>follow-up<span class="_ _3"> </span>clinical<span class="_ _3"> </span>and</div><div class="t m0 x1 h6 y12 ff4 fs1 fc0 sc0 ls0 ws0">biologic<span class="_ _5"> </span>data<span class="_ _5"> </span>were<span class="_ _5"> </span>used<span class="_ _5"> </span>as<span class="_ _5"> </span>the<span class="_ _5"> </span>best<span class="_ _5"> </span>valuable<span class="_ _5"> </span>comparator<span class="_ _5"> </span>to<span class="_ _5"> </span>de&#64257;ne<span class="_ _5"> </span>metastatic<span class="_ _5"> </span>status.<span class="_ _5"> </span>Diagnostic</div><div class="t m0 x1 h6 y13 ff4 fs1 fc0 sc0 ls0 ws0">effectiveness<span class="_ _9"> </span>of<span class="_ _9"> </span>MRIas<span class="_ _9"> </span>alone<span class="_ _9"> </span>was<span class="_ _9"> </span>compared<span class="_ _9"> </span>with<span class="_ _9"> </span>each<span class="_ _9"> </span>step<span class="_ _9"> </span>of<span class="_ _9"> </span>the<span class="_ _9"> </span>SW.<span class="_ _9"> </span>Impact<span class="_ _9"> </span>of<span class="_ _9"> </span>MRIas</div><div class="t m0 x1 h6 y14 ff4 fs1 fc0 sc0 ls0 ws0">screening<span class="_ _5"> </span>on<span class="_ _5"> </span>patient<span class="_ _5"> </span>management<span class="_ _5"> </span>and<span class="_ _5"> </span>costs<span class="_ _5"> </span>was<span class="_ _5"> </span>evaluated.</div><div class="t m0 x1 h5 y15 ff3 fs1 fc0 sc0 ls0 ws0">Results</div><div class="t m0 x1 h6 y16 ff4 fs1 fc0 sc0 ls0 ws0">On<span class="_ _a"> </span>the<span class="_ _a"> </span>basis<span class="_ _a"> </span>of<span class="_ _a"> </span>the<span class="_ _a"> </span>best<span class="_ _a"> </span>valuable<span class="_ _a"> </span>comparator,<span class="_ _a"> </span>41<span class="_ _a"> </span>patients<span class="_ _a"> </span>(62%)<span class="_ _a"> </span>had<span class="_ _a"> </span>bone<span class="_ _a"> </span>metastases.</div><div class="t m0 x1 h6 y17 ff4 fs1 fc0 sc0 ls0 ws0">Sensitivities<span class="_ _0"> </span>were<span class="_ _0"> </span>46%<span class="_ _0"> </span>for<span class="_ _7"> </span>BS<span class="_ _0"> </span>alone,<span class="_ _0"> </span>63%<span class="_ _0"> </span>for<span class="_ _0"> </span>BS/TXR,<span class="_ _0"> </span>83%<span class="_ _0"> </span>for<span class="_ _0"> </span>BS/TXR/MRIor,<span class="_ _0"> </span>and<span class="_ _0"> </span>100%<span class="_ _7"> </span>for</div><div class="t m0 x1 h6 y18 ff4 fs1 fc0 sc0 ls0 ws0">MRIas;<span class="_ _0"> </span>the<span class="_ _0"> </span>corresponding<span class="_ _7"> </span>speci&#64257;cities<span class="_ _0"> </span>were<span class="_ _0"> </span>32%,<span class="_ _0"> </span>64%,<span class="_ _0"> </span>100%,<span class="_ _0"> </span>and<span class="_ _0"> </span>88%,<span class="_ _0"> </span>respectively.<span class="_ _0"> </span>MRIas</div><div class="t m0 x1 h6 y19 ff4 fs1 fc0 sc0 ls0 ws0">was<span class="_ _5"> </span>signi&#64257;cantly<span class="_ _5"> </span>more<span class="_ _7"> </span>sensitive<span class="_ _5"> </span>than<span class="_ _7"> </span>any<span class="_ _5"> </span>other<span class="_ _5"> </span>approach<span class="_ _7"> </span>(<span class="ff5">P<span class="_ _5"> </span><span class="ff6">&#11021;<span class="_ _7"> </span></span></span>.05,<span class="_ _5"> </span>McNemar).<span class="_ _5"> </span>MRIas<span class="_ _7"> </span>identi&#64257;ed</div><div class="t m0 x1 h6 y1a ff4 fs1 fc0 sc0 ls0 ws0">metastases<span class="_ _0"> </span>in<span class="_ _7"> </span>seven<span class="_ _0"> </span>(30%)<span class="_ _0"> </span>of<span class="_ _7"> </span>23<span class="_ _0"> </span>patients<span class="_ _0"> </span>considered<span class="_ _0"> </span>negative<span class="_ _7"> </span>and<span class="_ _0"> </span>eight<span class="_ _0"> </span>(47%)<span class="_ _7"> </span>of<span class="_ _0"> </span>17<span class="_ _0"> </span>patients</div><div class="t m0 x1 h6 y1b ff4 fs1 fc0 sc0 ls0 ws0">considered<span class="_ _7"> </span>equivocal<span class="_ _0"> </span>by<span class="_ _0"> </span>other<span class="_ _7"> </span>strategies,<span class="_ _0"> </span>which<span class="_ _0"> </span>altered<span class="_ _7"> </span>the<span class="_ _0"> </span>initially<span class="_ _0"> </span>planned<span class="_ _7"> </span>therapy.<span class="_ _0"> </span>Economic</div><div class="t m0 x1 h6 y1c ff4 fs1 fc0 sc0 ls0 ws0">impact<span class="_ _5"> </span>was<span class="_ _5"> </span>variable<span class="_ _5"> </span>among<span class="_ _5"> </span>countries,<span class="_ _5"> </span>depending<span class="_ _5"> </span>on<span class="_ _5"> </span>reimbursement<span class="_ _5"> </span>rates.</div><div class="t m0 x1 h5 y1d ff3 fs1 fc0 sc0 ls0 ws0">Conclusion</div><div class="t m0 x1 h6 y1e ff4 fs1 fc0 sc0 ls2 ws0">MRIas<span class="_ _1"> </span>is<span class="_ _1"> </span>more<span class="_ _b"> </span>sensitive<span class="_ _b"> </span>than<span class="_ _1"> </span>the<span class="_ _1"> </span>current<span class="_ _b"> </span>SW<span class="_ _1"> </span>of<span class="_ _1"> </span>radiographically<span class="_ _b"> </span>identi&#64257;ed<span class="_ _1"> </span>bone<span class="_ _1"> </span>metastases<span class="_ _b"> </span>in<span class="_ _1"> </span>high-risk</div><div class="t m0 x1 h6 y1f ff4 fs1 fc0 sc0 ls2 ws0">PCa<span class="_ _4"> </span>patients,<span class="_ _4"> </span>which<span class="_ _5"> </span>impacts<span class="_ _4"> </span>the<span class="_ _4"> </span>clinical<span class="_ _5"> </span>management<span class="_ _4"> </span>of<span class="_ _4"> </span>a<span class="_ _5"> </span>signi&#64257;cant<span class="_ _4"> </span>proportion<span class="_ _4"> </span>of<span class="_ _5"> </span>patients.</div><div class="t m0 x1 h7 y20 ff5 fs1 fc0 sc0 ls2 ws0">J<span class="_ _4"> </span>Clin<span class="_ _4"> </span>Oncol<span class="_ _5"> </span>25:3281-3287.<span class="_ _4"> </span>&#169;<span class="_ _4"> </span>2007<span class="_ _5"> </span>by<span class="_ _4"> </span>American<span class="_ _4"> </span>Society<span class="_ _5"> </span>of<span class="_ _4"> </span>Clinical<span class="_ _4"> </span>Oncology</div><div class="t m0 x3 h5 y21 ff3 fs1 fc1 sc0 ls0 ws0">INTRODUCTION</div><div class="t m0 x1 h8 y22 ff1 fs3 fc0 sc0 ls3 ws0">Although<span class="_ _b"> </span>bone<span class="_ _1"> </span>metastases<span class="_ _b"> </span>represent<span class="_ _1"> </span>the<span class="_ _b"> </span>initial<span class="_ _1"> </span>met-</div><div class="t m0 x1 h8 y23 ff1 fs3 fc0 sc0 ls3 ws0">astatic<span class="_ _0"> </span>site<span class="_ _8"> </span>in<span class="_ _0"> </span>more<span class="_ _8"> </span>than<span class="_ _0"> </span>80%<span class="_ _8"> </span>of<span class="_ _0"> </span>prostate<span class="_ _0"> </span>cancer</div><div class="t m0 x1 h8 y24 ff1 fs3 fc0 sc0 ls3 ws0">(PCa)<span class="_ _3"> </span>patients,<span class="_ _3"> </span>there<span class="_ _3"> </span>has<span class="_ _3"> </span>been<span class="_ _3"> </span>no<span class="_ _3"> </span>major<span class="_ _3"> </span>break-</div><div class="t m0 x1 h8 y25 ff1 fs3 fc0 sc0 ls3 ws0">through<span class="_ _1"> </span>in<span class="_ _6"> </span>diagnostic<span class="_ _1"> </span>techniques.<span class="_ _1"> </span>The<span class="_ _6"> </span>detection<span class="_ _1"> </span>al-</div><div class="t m0 x1 h8 y26 ff1 fs3 fc0 sc0 ls3 ws0">gorithm<span class="_ _c"> </span>of<span class="_ _c"> </span>bone<span class="_ _c"> </span>metastases<span class="_ _c"> </span>still<span class="_ _c"> </span>relies<span class="_ _c"> </span>on</div><div class="t m0 x1 h8 y27 ff1 fs3 fc0 sc0 ls3 ws0">technetium-99m<span class="_ _d"> </span>bone<span class="_ _d"> </span>scintigraphy<span class="_ _d"> </span>(BS),<span class="_ _d"> </span>which</div><div class="t m0 x1 h8 y28 ff1 fs3 fc0 sc0 ls3 ws0">strikingly<span class="_ _4"> </span>lacks<span class="_ _5"> </span>diagnostic<span class="_ _4"> </span>speci&#64257;city.</div><div class="t m1 x4 h9 y29 ff1 fs4 fc0 sc0 ls4 ws0">1-4</div><div class="t m0 x5 h8 y2a ff1 fs3 fc0 sc0 ls3 ws0">Regions<span class="_ _4"> </span>of</div><div class="t m0 x1 h8 y2b ff1 fs3 fc0 sc0 ls3 ws0">increased<span class="_ _1"> </span>uptake<span class="_ _6"> </span>must<span class="_ _6"> </span>be<span class="_ _6"> </span>characterized<span class="_ _6"> </span>by<span class="_ _1"> </span>targeted</div><div class="t m0 x1 h8 y2c ff1 fs3 fc0 sc0 ls3 ws0">x-rays<span class="_ _8"> </span>(TXR)<span class="_ _0"> </span>to<span class="_ _8"> </span>distinguish<span class="_ _0"> </span>benign<span class="_ _8"> </span>(eg,<span class="_ _8"> </span>fracture,</div><div class="t m0 x1 h8 y2d ff1 fs3 fc0 sc0 ls3 ws0">Paget&#8217;s<span class="_ _3"> </span>disease,<span class="_ _8"> </span>degenerative<span class="_ _3"> </span>disease,<span class="_ _3"> </span>and<span class="_ _3"> </span>so<span class="_ _3"> </span>on)</div><div class="t m0 x1 h8 y2e ff1 fs3 fc0 sc0 ls3 ws0">from<span class="_ _b"> </span>metastatic<span class="_ _b"> </span>lesions.</div><div class="t m1 x6 h9 y2f ff1 fs4 fc0 sc0 ls0 ws0">5</div><div class="t m0 x7 h8 y30 ff1 fs3 fc0 sc0 ls3 ws0">This<span class="_ _b"> </span>BS/TXR<span class="_ _b"> </span>association<span class="_ _e"> </span>is</div><div class="t m0 x1 h8 y31 ff1 fs3 fc0 sc0 ls3 ws0">imperfect,<span class="_ _6"> </span>and<span class="_ _1"> </span>the<span class="_ _6"> </span>diagnosis<span class="_ _6"> </span>often<span class="_ _6"> </span>remains<span class="_ _6"> </span>equivo-</div><div class="t m0 x8 h8 y32 ff1 fs3 fc0 sc0 ls3 ws0">cal<span class="_ _1"> </span>without<span class="_ _1"> </span>the<span class="_ _6"> </span>additional<span class="_ _1"> </span>use<span class="_ _1"> </span>of<span class="_ _1"> </span>computed<span class="_ _6"> </span>tomog-</div><div class="t m0 x8 h8 y33 ff1 fs3 fc0 sc0 ls3 ws0">raphy<span class="_ _b"> </span>(CT)<span class="_ _e"> </span>or<span class="_ _b"> </span>magnetic<span class="_ _b"> </span>resonance<span class="_ _b"> </span>imaging<span class="_ _b"> </span>(MRI).</div><div class="t m1 x9 h9 y34 ff1 fs4 fc0 sc0 ls0 ws0">6</div><div class="t m0 x8 h8 y35 ff1 fs3 fc0 sc0 ls3 ws0">Therefore,<span class="_ _6"> </span>MRI<span class="_ _4"> </span>cost<span class="_ _6"> </span>is<span class="_ _4"> </span>added<span class="_ _6"> </span>to<span class="_ _4"> </span>the<span class="_ _6"> </span>BS/TXR<span class="_ _4"> </span>costs,</div><div class="t m0 x8 h8 y36 ff1 fs3 fc0 sc0 ls3 ws0">and<span class="_ _4"> </span>this<span class="_ _4"> </span>multistep<span class="_ _5"> </span>approach<span class="_ _4"> </span>can<span class="_ _4"> </span>become<span class="_ _5"> </span>inconve-</div><div class="t m0 x8 h8 y37 ff1 fs3 fc0 sc0 ls3 ws0">nient<span class="_ _1"> </span>to<span class="_ _b"> </span>patients.</div><div class="t m0 xa h8 y38 ff1 fs3 fc0 sc0 ls3 ws0">The<span class="_ _1"> </span>sensitivity<span class="_ _1"> </span>of<span class="_ _1"> </span>MRI<span class="_ _1"> </span>to<span class="_ _1"> </span>detect<span class="_ _1"> </span>bone<span class="_ _1"> </span>metasta-</div><div class="t m0 x8 h8 y39 ff1 fs3 fc0 sc0 ls3 ws0">ses<span class="_ _e"> </span>in<span class="_ _e"> </span>cancer<span class="_ _f"> </span>patients<span class="_ _f"> </span>has<span class="_ _e"> </span>been<span class="_ _e"> </span>highlighted<span class="_ _f"> </span>for<span class="_ _e"> </span>almost</div><div class="t m0 x8 h8 y3a ff1 fs3 fc0 sc0 ls3 ws0">20<span class="_ _6"> </span>years.</div><div class="t m1 xb h9 y3b ff1 fs4 fc0 sc0 ls4 ws0">5,7</div><div class="t m0 xc h8 y3c ff1 fs3 fc0 sc0 ls3 ws0">Its<span class="_ _6"> </span>superiority<span class="_ _6"> </span>over<span class="_ _6"> </span>BS<span class="_ _4"> </span>has<span class="_ _6"> </span>been<span class="_ _6"> </span>repeat-</div><div class="t m0 x8 h8 y3d ff1 fs3 fc0 sc0 ls3 ws0">edly<span class="_ _e"> </span>suggested.</div><div class="t m1 xd h9 y3e ff1 fs4 fc0 sc0 ls4 ws0">6,8-11</div><div class="t m0 xe h8 y3f ff1 fs3 fc0 sc0 ls3 ws0">It<span class="_ _e"> </span>has<span class="_ _b"> </span>even<span class="_ _e"> </span>been<span class="_ _b"> </span>used<span class="_ _e"> </span>as<span class="_ _b"> </span>the<span class="_ _b"> </span>gold</div><div class="t m0 x8 h8 y40 ff1 fs3 fc0 sc0 ls3 ws0">standard<span class="_ _0"> </span>to<span class="_ _8"> </span>evaluate<span class="_ _0"> </span>new<span class="_ _0"> </span>nuclear<span class="_ _8"> </span>medicine<span class="_ _0"> </span>tech-</div><div class="t m0 x8 h8 y41 ff1 fs3 fc0 sc0 ls3 ws0">niques<span class="_ _1"> </span>for<span class="_ _1"> </span>detecting<span class="_ _1"> </span>bones<span class="_ _1"> </span>metastases<span class="_ _6"> </span>and<span class="_ _1"> </span>more<span class="_ _1"> </span>re-</div><div class="t m0 x8 h8 y42 ff1 fs3 fc0 sc0 ls3 ws0">cently<span class="_ _9"> </span>to<span class="_ _9"> </span>quantify<span class="_ _3"> </span>PCa<span class="_ _9"> </span>metastases<span class="_ _9"> </span>and<span class="_ _9"> </span>measure</div><div class="t m0 x8 h8 y43 ff1 fs3 fc0 sc0 ls3 ws0">tumor<span class="_ _4"> </span>response<span class="_ _6"> </span>to<span class="_ _4"> </span>therapy.</div><div class="t m1 xf h9 y44 ff1 fs4 fc0 sc0 ls4 ws0">4,12,13</div><div class="t m0 x10 h8 y45 ff1 fs3 fc0 sc0 ls3 ws0">However,<span class="_ _4"> </span>the<span class="_ _6"> </span>use</div><div class="t m0 x8 h8 y46 ff1 fs3 fc0 sc0 ls3 ws0">of<span class="_ _1"> </span>MRI<span class="_ _1"> </span>in<span class="_ _1"> </span>&#64257;rst<span class="_ _1"> </span>line<span class="_ _1"> </span>is<span class="_ _1"> </span>often<span class="_ _1"> </span>presented<span class="_ _1"> </span>as<span class="_ _1"> </span>not<span class="_ _1"> </span>feasible</div><div class="t m0 x11 ha y47 ff4 fs4 fc0 sc0 ls0 ws0">From<span class="_ _1"> </span>the<span class="_ _b"> </span>Departments<span class="_ _1"> </span>of<span class="_ _1"> </span>Radiology,</div><div class="t m0 x11 ha y48 ff4 fs4 fc0 sc0 ls0 ws0">Urology,<span class="_ _1"> </span>and<span class="_ _b"> </span>Nuclear<span class="_ _1"> </span>Medicine,<span class="_ _1"> </span>Clin-</div><div class="t m0 x11 ha y49 ff4 fs4 fc0 sc0 ls0 ws0">iques<span class="_ _1"> </span>Universitaires<span class="_ _b"> </span>Saint<span class="_ _1"> </span>Luc,<span class="_ _1"> </span>Univer-</div><div class="t m0 x11 ha y4a ff4 fs4 fc0 sc0 ls0 ws0">sit&#233;<span class="_ _1"> </span>Catholique<span class="_ _b"> </span>de<span class="_ _1"> </span>Louvain;<span class="_ _1"> </span>European</div><div class="t m0 x11 ha y4b ff4 fs4 fc0 sc0 ls0 ws0">Organisation<span class="_ _1"> </span>for<span class="_ _b"> </span>Research<span class="_ _1"> </span>and<span class="_ _1"> </span>Treat-</div><div class="t m0 x11 ha y4c ff4 fs4 fc0 sc0 ls0 ws0">ment<span class="_ _1"> </span>of<span class="_ _b"> </span>Cancer,<span class="_ _1"> </span>Brussels;<span class="_ _1"> </span>Center<span class="_ _1"> </span>of</div><div class="t m0 x11 ha y4d ff4 fs4 fc0 sc0 ls0 ws0">Biostatistics,<span class="_ _1"> </span>Mont<span class="_ _b"> </span>Godinne<span class="_ _1"> </span>University</div><div class="t m0 x11 ha y4e ff4 fs4 fc0 sc0 ls0 ws0">Hospital,<span class="_ _1"> </span>Yvoir,<span class="_ _b"> </span>Belgium;<span class="_ _1"> </span>and<span class="_ _1"> </span>the</div><div class="t m0 x11 ha y4f ff4 fs4 fc0 sc0 ls0 ws0">Department<span class="_ _1"> </span>of<span class="_ _b"> </span>Radiology,<span class="_ _1"> </span>Beth<span class="_ _1"> </span>Israel</div><div class="t m0 x11 ha y50 ff4 fs4 fc0 sc0 ls0 ws0">Deaconess<span class="_ _1"> </span>Medical<span class="_ _b"> </span>Center,<span class="_ _1"> </span>Harvard</div><div class="t m0 x11 ha y51 ff4 fs4 fc0 sc0 ls0 ws0">Medical<span class="_ _1"> </span>School,<span class="_ _b"> </span>Boston,<span class="_ _1"> </span>MA.</div><div class="t m0 x11 ha y52 ff4 fs4 fc0 sc0 ls5 ws0">Submitted<span class="_ _b"> </span>October<span class="_ _1"> </span>8,<span class="_ _b"> </span>2006;<span class="_ _1"> </span>accepted</div><div class="t m0 x11 ha y53 ff4 fs4 fc0 sc0 ls5 ws0">April<span class="_ _b"> </span>27,<span class="_ _1"> </span>2007.</div><div class="t m0 x11 ha y54 ff4 fs4 fc0 sc0 ls0 ws0">Supported<span class="_ _1"> </span>by<span class="_ _b"> </span>an<span class="_ _1"> </span>educational<span class="_ _1"> </span>grant<span class="_ _1"> </span>from</div><div class="t m0 x11 ha y55 ff4 fs4 fc0 sc0 ls0 ws0">the<span class="_ _1"> </span>nonpro&#64257;t<span class="_ _b"> </span>organization<span class="_ _1"> </span>Fondation</div><div class="t m0 x11 ha y56 ff4 fs4 fc0 sc0 ls0 ws0">Saint-Luc<span class="_ _1"> </span>(F.E.L.<span class="_ _b"> </span>and<span class="_ _1"> </span>B.T.).</div><div class="t m0 x11 ha y57 ff4 fs4 fc0 sc0 ls0 ws0">Authors&#8217;<span class="_ _1"> </span>disclosures<span class="_ _b"> </span>of<span class="_ _1"> </span>potential<span class="_ _1"> </span>con-</div><div class="t m0 x11 ha y58 ff4 fs4 fc0 sc0 ls0 ws0">&#64258;icts<span class="_ _1"> </span>of<span class="_ _b"> </span>interest<span class="_ _1"> </span>and<span class="_ _1"> </span>author<span class="_ _1"> </span>contribu-</div><div class="t m0 x11 ha y59 ff4 fs4 fc0 sc0 ls0 ws0">tions<span class="_ _1"> </span>are<span class="_ _b"> </span>found<span class="_ _1"> </span>at<span class="_ _1"> </span>the<span class="_ _1"> </span>end<span class="_ _1"> </span>of<span class="_ _b"> </span>this</div><div class="t m0 x11 ha y5a ff4 fs4 fc0 sc0 ls0 ws0">article.</div><div class="t m0 x11 ha y5b ff4 fs4 fc0 sc0 ls0 ws0">Address<span class="_ _1"> </span>reprint<span class="_ _b"> </span>requests<span class="_ _1"> </span>to<span class="_ _1"> </span>Fr&#233;d&#233;ric<span class="_ _1"> </span>E.</div><div class="t m0 x11 ha y5c ff4 fs4 fc0 sc0 ls0 ws0">Lecouvet,<span class="_ _1"> </span>MD,<span class="_ _b"> </span>PhD,<span class="_ _1"> </span>Saint-Luc<span class="_ _1"> </span>Univer-</div><div class="t m0 x11 ha y5d ff4 fs4 fc0 sc0 ls0 ws0">sity<span class="_ _1"> </span>Hospital,<span class="_ _b"> </span>Department<span class="_ _1"> </span>of<span class="_ _1"> </span>Radiology,</div><div class="t m0 x11 ha y5e ff4 fs4 fc0 sc0 ls0 ws0">Hippocrate<span class="_ _1"> </span>Ave<span class="_ _b"> </span>10/2942,<span class="_ _1"> </span>B-1200<span class="_ _1"> </span>Brus-</div><div class="t m0 x11 ha y5f ff4 fs4 fc0 sc0 ls0 ws0">sels,<span class="_ _1"> </span>Belgium;<span class="_ _b"> </span>e-mail:<span class="_ _1"> </span>lecouvet@</div><div class="t m0 x11 ha y60 ff4 fs4 fc0 sc0 ls0 ws0">rdgn.ucl.ac.be.</div><div class="t m0 x11 ha y61 ff4 fs4 fc0 sc0 ls0 ws0">&#169;<span class="_ _1"> </span>2007<span class="_ _b"> </span>by<span class="_ _1"> </span>American<span class="_ _1"> </span>Society<span class="_ _1"> </span>of<span class="_ _1"> </span>Clinical</div><div class="t m0 x11 ha y62 ff4 fs4 fc0 sc0 ls0 ws0">Oncology</div><div class="t m0 x11 ha y63 ff4 fs4 fc0 sc0 ls0 ws0">0732-183X/07/2522-3281/$20.00</div><div class="t m0 x11 ha y64 ff4 fs4 fc0 sc0 ls0 ws0">DOI:<span class="_ _1"> </span>10.1200/JCO.2006.09.2940</div><div class="t m0 x12 hb y65 ff7 fs5 fc0 sc0 ls0 ws0">J<span class="fs6">OURNAL<span class="_ _8"> </span>OF<span class="_ _8"> </span></span>C<span class="fs6">LINICAL<span class="_ _8"> </span></span>O<span class="fs6">NCOLOGY</span></div><div class="t m0 x13 hc y66 ff8 fs1 fc1 sc0 ls6 ws0">ORIGINAL<span class="_"> </span>REPORT</div><div class="t m0 x12 hd y67 ff8 fs4 fc0 sc0 ls7 ws0">VOLUME<span class="_ _10"> </span>25<span class="_ _10"> </span><span class="ff9 ls0">&#18528;<span class="_ _11"> </span></span>NUMBER<span class="_ _10"> </span>22<span class="_ _10"> </span><span class="ff9 ls0">&#18528;<span class="_ _11"> </span></span>AUGUST<span class="_ _10"> </span>1<span class="_ _10"> </span>2007</div><div class="t m0 x14 he y68 ff3 fs7 fc0 sc0 ls0 ws0">3281</div><div class="t m0 x15 hf y69 ffa fs2 fc2 sc0 ls0 ws0">Downloaded from ascopubs.org by 158.109.64.200 on November 24, 2017 from 158.109.064.200</div><div class="t m0 x16 hf y6a ffa fs2 fc2 sc0 ls0 ws0">Copyright &#169; 2017 American Society of Clinical Oncology. All rights reserved.</div></div><div class="pi" data-data='{"ctm":[1.641026,0.000000,0.000000,1.641026,-14.769231,-14.769231]}'></div></div> </body> </html>
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